Oh, friends, this Meat Lovers Pizza Casserole is about to be your new favorite weeknight meal. If you’re a fan of pizza (who isn’t?), you’ll love this twist on the classic. Imagine layers of savory meat, gooey cheese, and perfectly seasoned pasta, all coming together in one hearty dish that’s comforting, satisfying, and packed with flavor. Seriously, trust me when I say that this recipe is about to rock your world. It’s like pizza and casserole had a beautiful baby, and it’s ready to take over your dinner table. So, grab your ingredients, and let’s get cooking!
Why You’ll Love Meat Lovers Pizza Casserole
This recipe isn’t just about the ingredients—it’s about creating moments. Whether you’re cooking for a casual family dinner, hosting a game day party, or just treating yourself to something delicious, this casserole has you covered. Here’s why it’s going to become your go-to:
Versatile: It’s perfect for a busy weeknight meal or a crowd-pleasing dish at gatherings. Just picture yourself coming home after a long day and knowing you’ve got this pizza-inspired casserole ready to go. Or imagine serving this to your friends and watching them swoon.
Budget-Friendly: No need for fancy ingredients here! This casserole is made with pantry staples and common ingredients that you probably already have at home. You can enjoy a hearty, flavorful meal without breaking the bank.
Quick and Easy: You don’t need to be a gourmet chef to make this dish. It’s a one-pan wonder that’s simple to throw together. If you’re new to cooking, don’t worry—you’ve totally got this!
Customizable: Want to switch up the meats? You do you! Add your favorite pizza toppings like mushrooms, green peppers, or even olives. This recipe is like a blank canvas just waiting for your personal touch.
Crowd-Pleasing: This casserole is bound to please everyone—from picky eaters to pizza lovers. Plus, kids? They’ll devour it. It’s cheesy, savory, and just downright irresistible.

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Ingredients
Here’s the magic behind this casserole—it’s made with simple, everyday ingredients, but the flavor is next-level. Let’s break it down:
Ground Beef: The hearty base that gives this casserole its satisfying, savory flavor. Ground beef brings that meaty goodness that makes this dish a real comfort food star.
Italian Sausage: For an extra layer of flavor, the sausage adds a bit of spice and richness to the mix, taking the meat lover’s dream up a notch.
Pepperoni: Ah, pepperoni—because every pizza deserves a few slices of this classic topping. It’s crispy, flavorful, and totally melts into the casserole.
Mozzarella Cheese: Ooey, gooey, melty mozzarella is the cheesy dream of this casserole. It melts beautifully and ties everything together in the most delicious way.
Pizza Sauce: You can’t have pizza without pizza sauce, right? This gives the casserole that signature tangy, savory base we all love in pizza.
Pasta: A hearty, satisfying layer of pasta—think of it as the foundation for all those wonderful pizza toppings. You’ll want something that holds up to all that flavor, like penne or rotini.
(Note: Full ingredient list, including measurements, can be found in the recipe card below.)
Instructions
Let’s dive right in and get this flavorful casserole ready:
Preheat Your Oven
Start by preheating your oven to 375°F (190°C). This step gets your oven nice and hot, ensuring your casserole bakes evenly and the cheese melts perfectly.
Brown the Meats
In a large skillet, cook your ground beef and Italian sausage over medium heat until browned. Make sure to break up the meat into small crumbles as it cooks. Once browned, drain any excess fat. Stir in the pepperoni slices to warm them up and get them crispy. The smell is going to be heavenly, trust me!
Cook the Pasta
While the meat is cooking, bring a pot of salted water to a boil. Cook the pasta according to package directions until al dente. Drain and set aside.
Mix It All Together
In a large mixing bowl, combine the cooked pasta, the meaty mixture, and your pizza sauce. Stir everything together until well combined, ensuring the pasta is nicely coated with the sauce and meats.
Layer and Cheese It Up
Spread the pasta mixture evenly into a greased 9×13-inch baking dish. Sprinkle the mozzarella cheese generously over the top, covering the entire casserole. If you want, you can also add some Parmesan for extra cheesy goodness!
Bake to Perfection
Bake your casserole for about 20-25 minutes, or until the cheese is melted and bubbly. You’ll know it’s ready when the cheese is golden and just starting to brown on top. It’s okay if you peek inside—this dish smells amazing!
Let It Cool and Serve
Once it’s out of the oven, let the casserole cool for a few minutes. This helps the cheese set just right and makes it easier to slice and serve.
How to Serve Meat Lovers Pizza Casserole
This casserole is hearty enough to be the star of the show, but if you’re looking to make it even more special, try pairing it with one of these sides:
Crisp Green Salad: A light, fresh salad with a tangy vinaigrette is the perfect balance to the rich and cheesy casserole.
Garlic Bread: Serve with warm, buttery garlic bread to sop up any leftover sauce and add a little extra comfort to your meal.
Roasted Vegetables: For a burst of color and nutrition, pair this dish with roasted vegetables like zucchini, bell peppers, or a medley of carrots and onions.
Creamy Dips: You could also serve this with a side of ranch dressing, marinara, or even some creamy garlic dipping sauce. It’s a fun way to dip each bite!
Additional Tips
- Prep Ahead: You can brown the meat and cook the pasta the day before, saving you time when you’re ready to assemble and bake the casserole.
- Spice It Up: If you want a little extra heat, add red pepper flakes or a dash of cayenne pepper to the sauce.
- Double the Batch: This recipe doubles beautifully, so go ahead and make a bigger batch for meal prepping or feeding a crowd.
- Dietary Adjustments: Looking for a lighter version? Use lean turkey or chicken sausage and low-fat cheese to reduce the richness without sacrificing flavor.
FAQ Section
Q1: Can I use a different type of meat?
A1: Absolutely! Feel free to swap in ground turkey, chicken sausage, or even bacon for a fun twist.
Q2: Can I make this ahead of time?
A2: Yes! You can assemble the casserole up to 24 hours ahead of time and keep it in the fridge. Just bake it when you’re ready!
Q3: Can I freeze leftovers?
A3: Yes, this casserole freezes wonderfully! Just store it in an airtight container, and it’ll stay fresh for up to 3 months. Reheat in the oven or microwave when you’re ready to enjoy.
Q4: How do I reheat leftovers?
A4: Reheat in the oven at 350°F for 15-20 minutes or in the microwave in 30-second intervals until warmed through.
Q5: Can I add more veggies to the casserole?
A5: Yes! Feel free to toss in some chopped bell peppers, onions, or mushrooms to add extra flavor and texture.
Q6: Is this recipe good for meal prep?
A6: It’s perfect for meal prep! Just divide it into individual portions and store them in airtight containers for easy, grab-and-go lunches or dinners.
Conclusion
This Meat Lovers Pizza Casserole is about to become your new go-to comfort food. With its meaty layers, gooey cheese, and pizza-inspired flavors, it’s perfect for any occasion. Whether you’re making it for a weeknight dinner or serving it to guests, this casserole is sure to impress. So go ahead—treat yourself to something delicious, and enjoy every bite!
PrintMeat Lovers Pizza Casserole
This Meat Lovers Pizza Casserole is the ultimate comfort food, combining a savory blend of ground beef, turkey, pepperoni, and gooey cheese all layered on a crispy pizza crust. It’s the perfect meal for pizza lovers who want a hearty, satisfying dish! Ready in just under an hour and sure to please the whole family.
- Prep Time: 10 minutes
- Cook Time: 30 minutes
- Total Time: 40 minutes
- Yield: 6 servings 1x
- Category: Casserole, Dinner
- Method: Baking, Stovetop
- Cuisine: American, Italian
- Diet: Vegetarian
Ingredients
- 1 lb lean ground beef
- 1 lb ground turkey or chicken (substitute for pork sausage)
- 1 cup chopped turkey or beef pepperoni
- ¼ cup all-purpose flour
- 4 tsp Italian seasoning, divided
- 1 (26-oz) jar tomato basil pasta sauce
- 2 cups shredded mozzarella cheese
- 1 (13.8-oz) can refrigerated pizza crust dough
- 1 Tbsp olive oil
- 3 Tbsp grated Parmesan cheese
Instructions
- Preheat the oven: Preheat your oven to 375°F (190°C) and lightly grease a 9×13-inch baking dish.
- Cook the meats: In a large skillet, cook the ground beef and ground turkey (or chicken) over medium heat until browned. Drain any excess fat.
- Add pepperoni and seasoning: Stir in the turkey (or beef) pepperoni, 2 tsp of Italian seasoning, and flour. Cook for 1 minute.
- Simmer the sauce: Add the pasta sauce and simmer for 5-7 minutes, allowing the flavors to combine.
- Prepare the crust: Roll out the pizza crust dough and place it in the bottom of the prepared baking dish. Drizzle with olive oil and sprinkle with the remaining Italian seasoning.
- Add the meat sauce: Pour the meat sauce mixture over the crust and spread evenly. Top with shredded mozzarella and Parmesan cheese.
- Bake: Bake in the preheated oven for 20-25 minutes, or until the crust is golden and the cheese is bubbly. Let it cool for a few minutes before serving.
Notes
- You can substitute ground beef with ground pork sausage for a richer flavor.
- If you prefer a spicier dish, add crushed red pepper flakes to the sauce mixture.
- This casserole pairs great with a fresh salad or garlic bread for a complete meal.
Nutrition
- Serving Size: 1/8th of the casserole
- Calories: 450-500 kcal
- Sugar: 4g
- Sodium: 900mg
- Fat: 30g
- Saturated Fat: 9g
- Unsaturated Fat: 15g
- Trans Fat: 0g
- Carbohydrates: 20g
- Fiber: 2g
- Protein: 30g
- Cholesterol: 70mg